GDC-0349
GDC-0349 is an ATP-competitive inhibitor of mTOR that exhibits anticancer chemotherpeutic activity. GDC-0349 displays pre-clinical efficacy in vitro and in vivo.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18926277
| Cas No. |
1207360-89-1 |
|---|---|
| Purity |
≥98% |
| Formula |
C24H32N6O3 |
| Formula Wt. |
452.55 |
| IUPAC Name |
1-ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea |
| Synonym |
GDC0349 |
| Appearance |
Tan to yellow solid |
Pei Z, Blackwood E, Liu L, et al. Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349. ACS Med Chem Lett. 2012 Nov 29;4(1):103-7. PMID: 24900569.
