Flumazenil
Flumazenil is an antagonist at GABA-A receptors that is used as a stimulant to counteract the effects of benzodiazepines. Flumenazil inhibits benzodiazepine-induced sedation, motor impairment, and ventilator depression.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18924533
| Cas No. |
78755-81-4 |
|---|---|
| Purity |
≥98% |
| Formula |
C15H14FN3O3 |
| Formula Wt. |
303.29 |
| Chemical Name |
8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepinne-3-carboxylic acid ethyl ester |
| IUPAC Name |
ethyl8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate |
| Synonym |
Anexate; Ro-15-1788; Lanexat; Romazicon |
| Melting Point |
201-203°C |
| Solubility |
Soluble in water (128mg/L). |
| Appearance |
A white or almost white crystalline powder |
Rye DB, Bliwise DL, Parker K, et al. Modulation of vigilance in the primary hypersomnias by endogenous enhancement of GABAA receptors. Sci Transl Med. 2012 Nov 21;4(161):161ra151. PMID: 23175709.
Lader M. Benzodiazepines revisited–will we ever learn? Addiction. 2011 Dec;106(12):2086-109. PMID: 21714826.
