Fluconazole
Fluconazole is a triazole antifungal compound that inhibits fungal 14-α demethylase. Fluconazole is especially active against Candida and Cryptococcus.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18924167
| Cas No. |
86386-73-4 |
|---|---|
| Purity |
≥98% |
| Formula |
C13H12F2N6O |
| Formula Wt. |
306.27 |
| Chemical Name |
α-(2,4-Difluorophenyl)-α-(1H-1,2,4-triazol-1- ylmethyl)-1H-1,2,4-triazole-1-ethanol |
| IUPAC Name |
2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol |
| Synonym |
Biozolene; Diflucan; Elazor; Triflucan |
| Melting Point |
138-140°C |
| Solubility |
Slightly soluble in water 1mg/mL. Soluble in ethanol (61mg/mL), ethyl acetate and methanol. DMSO to 100 mM. |
| Appearance |
White to off white powder |
Cuenca-Estrella M. Antifungal agents in the treatment of systemic infections: Relevance of mechanism of action, activity profile and resistances. Rev Esp Quimioter. 2010 Dec;23(4):169-76. PMID: 21191554.
Mansfield BE, Oltean HN, Oliver BG, et al. Azole drugs are imported by facilitated diffusion in Candida albicans and other pathogenic fungi. PLoS Pathog. 2010 Sep 30;6(9):e1001126. PMID: 20941354.
Matsumoto Y, Miyazaki S, Fukunaga DH, et al. Quantitative evaluation of cryptococcal pathogenesis and antifungal drugs using a silkworm infection model with Cryptococcus neoformans. J Appl Microbiol. 2012 Jan;112(1):138-146. PMID: 22040451.
