Flubendazole
Flubendazole is a benzimidazole compound that inhibits microtubule polymerization; it exhibits anti-parasitic and anticancer chemotherapeutic activities. Flubendazole displays anti-helminthic benefit against Haemonchus and Trichomonas. When co-administered with vinblastine, flubendazole decreases in vitro cell viability and in vivo tumor growth in leukemia and myeloma models.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18924020
| Cas No. |
31430-15-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C16H12FN3O3 |
| Formula Wt. |
313.28 |
| Chemical Name |
[5-(4-Fluorobenzoyl)-1H-benzimidazole-2-yl]carbamic acid methyl ester |
| IUPAC Name |
methyl N-[6-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate |
| Synonym |
Flubenol; Flumoxal; Flumoxane; Fluvermal |
| Melting Point |
260°C |
| Solubility |
Insoluble in water. |
| Appearance |
White or Almost White Powder |
Spagnuolo PA, Hu J, Hurren R, et al. The antihelmintic flubendazole inhibits microtubule function through a mechanism distinct from Vinca alkaloids and displays preclinical activity in leukemia and myeloma. Blood. 2010 Jun 10;115(23):4824-33. PMID: 20348394.
Juliano C, Martinotti MG, Cappuccinelli P. “In vitro” effect of microtubule inhibitors on Trichomonas vaginalis. Microbiologica. 1985 Jan;8(1):31-42. PMID: 3871893.
