Floxuridine
Floxuridine is a fluorinated pyrimidine; it is an analog of 5-fluorouracil (5-FU). Floxuridine exhibits antiviral and anticancer chemotherapeutic activities. Floxuridine acts as an antimetabolite, inhibiting thymidylate synthase and inducing apoptosis in cancer cells. This compound also inhibits replication of dengue virus.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18923870
| Cas No. |
50-91-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C9H11FN2O5 |
| Formula Wt. |
246.19 |
| Chemical Name |
2-Deoxy-5-fluorouridine |
| IUPAC Name |
5-fluoro-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione |
| Synonym |
NSC-27640; FUDR |
| Melting Point |
150-151°C |
| Solubility |
Soluble in water. |
| Appearance |
White Crystalline |
Fischer MA, Smith JL, Shum D, et al. Flaviviruses are sensitive to inhibition of thymidine synthesis pathways. J Virol. 2013 Sep;87(17):9411-9. PMID: 23824813.
Muñoz-Pinedo C, Robledo G, López-Rivas A. Thymidylate synthase inhibition triggers glucose-dependent apoptosis in p53-negative leukemic cells. FEBS Lett. 2004 Jul 16;570(1-3):205-10. PMID: 15251465.
Tobias SC, Borch RF. Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs. J Med Chem. 2001 Dec 6;44(25):4475-80. PMID: 11728193.
