Florfenicol
Florfenicol is a synthetic fluorinated analog of thiamphenicol that exhibits antibiotic activity in livestock. Florfenicol acts as an antibacterial against Shigella, Escherichia, Klebsiella, Enterobacter, and Haemophilus. Florfenicol binds 23S rRNA on the bacterial 50S ribosome, inhibiting translation.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18923806
| Cas No. |
73231-34-2 |
|---|---|
| Purity |
≥98% |
| Formula |
C12H14Cl2FNO4S |
| Formula Wt. |
358.21 |
| Chemical Name |
2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-methylsulfonyl)-phenyl]ethyl]acetamide |
| IUPAC Name |
2,2-dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide |
| Synonym |
Fluorothiamphenicol; Aquafen |
| Melting Point |
153-154°C |
| Solubility |
Acetone, DMF. Slightly soluble in water (1.3 mg/ml). |
| Appearance |
White or off-white Crystalline Powder |
Kehrenberg C, Schwarz S, Jacobsen L, et al. A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Mol Microbiol. 2005 Aug;57(4):1064-73. PMID: 16091044.
Syriopoulou VP, Harding AL, Goldmann DA, et al. In vitro antibacterial activity of fluorinated analogs of chloramphenicol and thiamphenicol. Antimicrob Agents Chemother. 1981 Feb;19(2):294-7. PMID: 6957162.
