FLI-06
FLI-06 is a dihydropyridine inhibitor of γ-secretase that suppresses Notch signaling in vitro and in vivo. FLI-06 inhibits protein secretion prior to endoplasmic reticulum exit. Like other Notch signaling inhibitors, FLI-06 likely displays neuroprotective activity.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18923670
| Cas No. |
313967-18-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C25H30N2O5 |
| Formula Wt. |
438.52 |
| Chemical Name |
1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester |
| IUPAC Name |
Cyclohexyl 2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-1,4,5,6,7,8-hexahydro-3-quinolinecarboxylate |
| Appearance |
Yellow crystal powder |
Krämer A, Mentrup T, Kleizen B, et al. Small molecules intercept Notch signaling and the early secretory pathway. Nat Chem Biol. 2013 Nov;9(11):731-8. PMID: 24077179.
