Esculin
Esculin is a coumarin glucoside found in Aesculus, Daphne, and Bursaria. Esculin exhibits anti-diabetic and antioxidative activities. Esculin is hydrolyzed by species of Streptococcus, Enterococcus, Listeria, and Aerococcus and is used in research models to identify these bacteria. In diabetic rats, esculin decreases blood glucose and glucose-6-phosphatase levels and increases glucose uptake, potentially through the activation of insulin receptors, Akt, and GSK3β. Additionally, esculin decreases lipid peroxidation and increases levels of glutathione, glutathione peroxidase, glutathione-S-transferase, superoxide dismutase, and catalase in the kidneys of animals treated with pro-oxidant aflatoxin B1.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18922386
| Cas No. |
531-75-9 |
|---|---|
| Purity |
≥97% |
| Formula |
C15H16O9 |
| Formula Wt. |
340.28 |
| Chemical Name |
6-(β-D-Glucopyranosyloxy)-7-hydroxy-2H-1- benzopyran-2-one |
| IUPAC Name |
7-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one |
| Synonym |
Esculin hydrate; Esculoside; Bicolorin; Enallachrome; Polychrome; Escosyl |
| Melting Point |
203-205°C |
| Solubility |
Slightly soluble in water. Soluble in methanol |
| Appearance |
White to off white powder |
Kang KS, Lee W, Jung Y, et al. Protective effect of esculin on streptozotocin-induced diabetic renal damage in mice. J Agric Food Chem. 2014 Mar 5;62(9):2069-76. PMID: 24484395.
Naaz F, Abdin MZ, Javed S. Protective effect of esculin against prooxidant aflatoxin B1-induced nephrotoxicity in mice. Mycotoxin Res. 2014 Feb;30(1):25-32. PMID: 24326591.
Raemy A, Meylan M, Casati S, et al. Phenotypic and genotypic identification of streptococci and related bacteria isolated from bovine intramammary infections. Acta Vet Scand. 2013 Jul 18;55:53. PMID: 23866930.
