Erythromycin
Erythromycin is a macrolide antibiotic that binds the 50s subunit of bacterial ribosomes, inhibiting protein synthesis by preventing transfer of tRNA from the A site to the P site. This compound displays antibacterial activity against both gram positive and gram negative bacteria; it also inhibits mammalian mRNA splicing.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18922125
| Cas No. |
114-07-8 |
|---|---|
| Purity |
≥94% |
| Formula |
C37H67NO13 |
| Formula Wt. |
733.93 |
| Chemical Name |
Erythromycin A |
| IUPAC Name |
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-7,12,13-trihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione |
| Synonym |
Abomacetin; Aknin; EMU; E-Mycin; Erymax; Erycen; Erycin. |
| Melting Point |
135-140°C |
| Solubility |
Very slightly soluble in water (~2 mg/ml). Freely soluble in alcohols, acetone, ethyl acetate, acetonitrile or chloroform. |
| Appearance |
White Crystal Powder |
Hertweck M, Hiller R, Mueller MW. Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro. Eur J Biochem. 2002 Jan;269(1):175-83. PMID: 11784311.
Menninger JR, Otto DP. Erythromycin, carbomycin, and spiramycin inhibit protein synthesis by stimulating the dissociation of peptidyl-tRNA from ribosomes. Antimicrob Agents Chemother. 1982 May;21(5):811-8. PMID: 6179465.
