Ergosterol
Ergosterol is a sterol component of cell membranes in yeast and fungi. Ergosterol is a target for many antifungal compounds. Ergosterol exhibits anti-angiogenic, anticancer chemotherapeutic, and chemopreventive activities. In animal models of bladder cancer, ergosterol inhibits tumor promotion. Ergosterol also inhibits neovascularization and decreases tumor growth in animal models of sarcoma.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18922017
| Cas No. |
57-87-4 |
|---|---|
| Purity |
≥96% |
| Formula |
C28H44O |
| Formula Wt. |
396.65 |
| Chemical Name |
(3β,5α)-Ergostan-3-ol |
| IUPAC Name |
(3S,9S,10R,13R,14R,17R)-17-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol |
| Synonym |
Ergosterin, Provitamin D2. |
| Melting Point |
168°C |
| Solubility |
Practically insoluble in water. Soluble in chloroform, boiling ether, boiling alcohol. |
| Appearance |
White or almost white crystalline |
Roberts CW, McLeod R, Rice DW, et al. Fatty acid and sterol metabolism: potential antimicrobial targets in apicomplexan and trypanosomatid parasitic protozoa. Mol Biochem Parasitol. 2003 Feb;126(2):129-42. PMID: 12615312.
Takaku T, Kimura Y, Okuda H. Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr. 2001 May;131(5):1409-13. PMID: 11340091.
Yazawa Y, Yokota M, Sugiyama K. Antitumor promoting effect of an active component of Polyporus, ergosterol and related compounds on rat urinary bladder carcinogenesis in a short-term test with concanavalin A. Biol Pharm Bull. 2000 Nov;23(11):1298-302. PMID: 11085355.
