Entecavir
Entecavir is a cyclopentane class nucleoside analog of deoxyguanosine. Entecavir exhibits antiviral activity and is used clinically to treat hepatitis B infections. Entecavir binds to reverse transcriptase and gets incorporated into DNA, causing chain termination and preventing protein synthesis. This compound may also inhibit HIV-1 reverse transcriptase as well.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1891440
| Cas No. |
142217-69-4 |
|---|---|
| Purity |
≥97% |
| Formula |
C12H15N5O3 |
| Formula Wt. |
277.28 |
| Chemical Name |
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one |
| IUPAC Name |
2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-3H-purin-6-one |
| Melting Point |
230-240C |
| Solubility |
Water (2-3 mg/ml)DMSOMethanol |
| Appearance |
White to off white powder |
Yurdaydin C. Entecavir: a step forward in combating hepatitis B disease. Expert Opin Pharmacother. 2008 Dec;9(17):3095-109. PMID: 19006481.
Cheng PN, Chang TT. Entecavir: a potent antiviral with minimal long-term resistance in nucleoside-naive chronic hepatitis B patients. Expert Rev Anti Infect Ther. 2008 Oct;6(5):569-79. PMID: 18847396.
Domaoal RA, McMahon M, Thio CL, et al. Pre-steady-state kinetic studies establish entecavir 5-triphosphate as a substrate for HIV-1 reverse transcriptase. J Biol Chem. 2008 Feb 29;283(9):5452-9. PMID: 17962184.
Langley DR, Walsh AW, Baldick CJ, et al. Inhibition of hepatitis B virus polymerase by entecavir. J Virol. 2007 Apr;81(8):3992-4001. PMID: 17267485.
