Ebselen
Ebselen is a synthetic glutathione peroxidase mimetic that reacts with cysteine residues; it exhibits antimicrobial, antibacterial, anti-diabetic, and antioxidative activities. Ebselen increases ROS and mitochondrial membrane potential, inhibiting GDH function in vitro. Additionally, ebselen inhibits yeast sporulation and binds the Mycobacterium Ag85 complex, preventing outer membrane synthesis. In diabetic rats, this compound prevents hyperglycemia, decreases glucose levels, Hb1Ac, and oxidative stress, and increases β-cell mass.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1890115
| Cas No. |
60940-34-3 |
|---|---|
| Purity |
≥98% |
| Formula |
C13H9NOSe |
| Formula Wt. |
274.18 |
| IUPAC Name |
2-phenyl-1,2-benzoselenazol-3-one |
| Synonym |
2-Phenyl-1,2-benzisoselenazolin-3-one |
| Melting Point |
180-181°C |
| Solubility |
Soluble in DMSO. |
| Appearance |
White Solid |
Azad GK, Singh V, Mandal P, et al. Ebselen induces reactive oxygen species (ROS)-mediated cytotoxicity in Saccharomyces cerevisiae with inhibition of glutamate dehydrogenase being a target. FEBS Open Bio. 2014 Jan 6;4:77-89. PMID: 24490132.
Favrot L, Grzegorzewicz AE, Lajiness DH, et al. Mechanism of inhibition of Mycobacterium tuberculosis antigen 85 by ebselen. Nat Commun. 2013;4:2748. PMID: 24193546.
Mahadevan J, Parazzoli S, Oseid E, et al. Ebselen treatment prevents islet apoptosis, maintains intranuclear Pdx-1 and MafA levels, and preserves β-cell mass and function in ZDF rats. Diabetes. 2013 Oct;62(10):3582-8. PMID: 23801580.
