E-JIB-04
This compound is the E stereoisomer of JIB-04, an inhibitor of Jumonji family histone demethylases; it does not inhibit activity of α-ketoglutarate. JIB-04 exhibits anticancer chemotherapeutic activity, inhibiting protein translation initiation. In cancer models, JIB-04 inhibits cell viability, decreases tumor burden, and increases survival rates.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18897921
| Cas No. |
199596-05-9 |
|---|---|
| Formula |
C17H13ClN4 |
| Formula Wt. |
308.77 |
| Chemical Name |
(E)-N-(5-Chloro-pyridin-2-yl)-N′-(phenyl-pyridin-2-yl-methylene)-hydrazine |
| IUPAC Name |
5-Chloro-2-{(2E)-2-[phenyl(2-pyridinyl)methylene]hydrazino}pyridine |
| Synonym |
NSC 693627, JHDM inhibitor VII |
Van Rechem C, Black JC, Boukhali M, et al. Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis. Cancer Discov. 2015 Mar;5(3):255-63. PMID: 25564516.
Wang L, Chang J, Varghese D, et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat Commun. 2013;4:2035. Erratum in: Nat Commun. 2013;4:2639. PMID: 23792809.
