E64-d
E64d is an inhibitor of cathepsins that exhibits neuroprotective activity. In vivo, E64d inhibits cathepsin D, decreasing brain amyloid-β (Aβ) plaque formation. E64d inhibition of cathepsins also aggravates left ventricular dysfunction in animal models of myocardial infarction.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1889950
| Cas No. |
88321-09-9 |
|---|---|
| Purity |
≥97% |
| Formula |
C17H30N2O5 |
| Formula Wt. |
342.43 |
| IUPAC Name |
ethyl (2S,3S)-3-[[(2S)-4-methyl-1-(3-methylbutylamino)-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate |
| Synonym |
Aloxistatin |
| Appearance |
White Crystal Powder |
Hook G, Yu J, Toneff T, et al. Brain Pyroglutamate Amyloid-Beta is Produced by Cathepsin B and is Reduced by the Cysteine Protease Inhibitor E64d, Representing a Potential Alzheimers Disease Therapeutic. J Alzheimers Dis. 2014 Mar 4. [Epub ahead of print]. PMID: 24595198.
Chen H, Wang J, Xiang MX, et al. Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction. Cardiovasc Res. 2013 Oct 1;100(1):84-94. PMID: 23771947.
