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Domperidone

Domperidone is an antagonist at D2/3 receptors that is clinically used to treat nausea, induce prolactin release, and increase gastrointestinal transit speed. Domperidone exhibits antiemetic, antinociceptive, analgesic, and prokinetic gastrointestinal motility modulating activities. In animals undergoing the formalin test, domperidone decreases overall pain score. Domperidone also inhibits human ether-a-go-go-related (hERG) K+ channel currents, prolonging the QT interval.

References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18890813,15442734,15431618,14794887,14771065,14381280,14289196,14246669,14240630,14135731,14131801,14131769,14100681,14068047,14055735,13924604,13901598,13782168,13675736,13413265,13395224,13263131,13222208,9400995,7964323,6037056,5964173,5888826,5812130,5805759,5631358,5616502,5409525,5395460,5366953,5173034,5030175,5022432,5012734,4975549,4830541,4733118,4688149,4653181,4434904,4421149,4336748,4304969,4302610,4177547,4175888,4167290,4162249,4138797,4124972,4106791,4105881,686391

Cas No.

57808-66-9
Purity

≥98%
Formula

C22H24ClN5O2
Formula Wt.

425.91
Chemical Name

5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H- benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro- 2H-benzimidazol-2-one
IUPAC Name

6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
Synonym

Euciton; Evoxin; Mod; Motilium; Nnauzelin: Peridon; Peridys
Melting Point

242.5°C
Solubility

Slightly soluble in water (0.986 mg/L). soluble in dimethylformamide, slightly soluble in alcohol and in methanol
Appearance

White Crystal Powder

Claassen S, Zünkler BJ. Comparison of the effects of metoclopramide and domperidone on HERG channels. Pharmacology. 2005 Apr;74(1):31-6. PMID: 15640612.

Sivasanker M, Reddy PM, Shashindran CH, et al. Formalin assay parameters differ in confirming the antinociceptive mechanism of domperidone in mice. Indian J Exp Biol. 2004 Apr;42(4):429-31. PMID: 15088695.

LDK-378