Difenoconazole
Difenoconazole is a triazole pesticide/fungicide with broad antifungal activity. Like many azole fungicides, difenoconazole likely inhibits 14-α demethylase, preventing ergosterol production and fungal cell wall synthesis. Additionally, difenoconazole may inhibit aromatase.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18865959
| Cas No. |
119446-68-3 |
|---|---|
| Purity |
≥98% |
| Formula |
C19H17Cl2N3O3 |
| Formula Wt. |
406.26 |
| Chemical Name |
1-((2-(2-chloro-4-(4-chlorophenoxy)phenyl)-4-methyl-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole |
| IUPAC Name |
1-[[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-yl]methyl]-1,2,4-triazole |
| Melting Point |
76°C |
| Appearance |
White Crystal Powder |
Kjærstad MB, Taxvig C, Nellemann C, et al. Endocrine disrupting effects in vitro of conazole antifungals used as pesticides and pharmaceuticals. Reprod Toxicol. 2010 Dec;30(4):573-82. PMID: 20708073.
Hinfray N, Porcher JM, Brion F. Inhibition of rainbow trout (Oncorhynchus mykiss) P450 aromatase activities in brain and ovarian microsomes by various environmental substances. Comp Biochem Physiol C Toxicol Pharmacol. 2006 Nov;144(3):252-62. PMID: 17081805.
Sanderson JT, Boerma J, Lansbergen GW, et al. Induction and inhibition of aromatase (CYP19) activity by various classes of pesticides in H295R human adrenocortical carcinoma cells. Toxicol Appl Pharmacol. 2002 Jul 1;182(1):44-54. PMID: 12127262.
