Diethylstilbestrol
Diethylstilbestrol is a synthetic non-steroidal estrogen that exhibits anticancer activity. Diethylstilbestrol was previously used to treat breast cancer, prostate cancer, vaginitis, symptoms of menopause, and in the prevention of miscarriage. This compound is no longer clinically used for these purposes and has since been classified as an endocrine disrupter.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18865621
| Cas No. |
56-53-1 |
|---|---|
| Purity |
≥98% |
| Formula |
C18H20O2 |
| Formula Wt. |
268.35 |
| Chemical Name |
4,4-[(1E)-1,2-Diethyl-1,2-ethenediyl]bisphenol |
| IUPAC Name |
4-[(E)-4-(4-hydroxyphenyl)hex-3-en-3-yl]phenol |
| Synonym |
Stilbestrol; DES; Apstil; Cyren A; Stilbetin |
| Melting Point |
169-172°C |
| Solubility |
Soluble in alcohol, ether, chloroform or fatty oils. Insoluble in water. |
| Appearance |
White Crystal Powder |
Ingle JN, Ahmann DL, Green SJ, et al. Randomized clinical trial of diethylstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer. N Engl J Med. 1981 Jan 1;304(1):16-21. PMID: 7001242.
Dieckmann WJ, Davis ME, Rynkiewicz LM, et al. Does the administration of diethylstilbestrol during pregnancy have therapeutic value? Am J Obstet Gynecol. 1953 Nov;66(5):1062-81. PMID: 13104505.
