Diaveridine
Diaveridine is a coccidiostat used in veterinary medicine that exhibits anti-parasitic activity. Diaveridine inhibits dihydrofolate reductase, preventing folic acid synthesis in species of Pneumocystis. Diaveridine is also genotoxic, inducing structural chromosomal aberrations and inducing DNA damage in vitro.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1886436
| Cas No. |
5355-16-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C13H16N4O2 |
| Formula Wt. |
260.29 |
| Chemical Name |
5-[(3,4-Dimethoxyphenyl)methyl]-2,4-pyrimidine- diamine |
| IUPAC Name |
5-[(3,4-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine |
| Synonym |
Diaveridin |
| Melting Point |
233°C |
| Solubility |
Soluble in HCl or chloroform (1:600). |
| Appearance |
White or Almost-White Crystalline Powder |
Ono T, Sekiya T, Takahashi Y, et al. The genotoxicity of diaveridine and trimethoprim. Environ Toxicol Pharmacol. 1997 Sep;3(4):297-306. PMID: 21781790.
Cirioni O, Giacometti A, Scalise G. In-vitro activity of atovaquone, sulphamethoxazole and dapsone alone and combined with inhibitors of dihydrofolate reductase and macrolides against Pneumocystis carinii. J Antimicrob Chemother. 1997 Jan;39(1):45-51. PMID: 9044027.
Walzer PD, Kim CK, Foy JM, et al. Inhibitors of folic acid synthesis in the treatment of experimental Pneumocystis carinii pneumonia. Antimicrob Agents Chemother. 1988 Jan;32(1):96-103. PMID: 3258144.
