Dehydroandrographolide
Dehydroandrographolide is a labdane diterpene found in Andrographis that exhibits antiviral, antioxidative, and anti-inflammatory activities. In vitro, this compound inhibits hepatitis B virus replication. Additionally, dehydroandrographolide decreases LPS-induced expression of TNF-α, IL-1β, IL-6, and malondialdehyde and increases levels of superoxide dismutase in animal models of lung injury.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18856230
| Purity |
≥98% |
|---|---|
| Formula |
C20H28O4 |
| Formula Wt. |
332.43 |
| Melting Point |
232-236°C |
| Solubility |
Soluble in chloroform |
| Appearance |
Off-White Powder |
Chen H, Ma YB, Huang XY, et al. Synthesis, structure-activity relationships and biological evaluation of dehydroandrographolide and andrographolide derivatives as novel anti-hepatitis B virus agents. Bioorg Med Chem Lett. 2014 May 15;24(10):2353-9. PMID: 24731274.
Zhu T, Guan X, Zhang W, et al. Dehydroandrographolide succinate inhibits oxidative stress in mice with lipopolysaccharide-induced acute lung injury by inactivating iNOS. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Sep;32(9):1238-41. PMID: 22985554.
