D-Sphingosine
D-Sphingosine is an endogenous component of sphingolipids that exhibits antibacterial activity against many gram positive and gram negative bacteria such as Escherichia, Staphylococcus, and Corynebacterium. D-Sphingosine also inhibits PKC.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18855614
| Cas No. |
123-78-4 |
|---|---|
| Purity |
≥98% |
| Formula |
C18H37NO2 |
| Formula Wt. |
299.49 |
| Chemical Name |
(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol |
| IUPAC Name |
(E,2S,3R)-2-aminooctadec-4-ene-1,3-diol |
| Synonym |
Sphingosine; 4-Sphingenine |
| Melting Point |
81-82°C |
| Solubility |
Soluble in chloroform, DMSO. Insoluble in ethanol, acetone, water. |
| Appearance |
Off- White Powder |
Fischer CL, Drake DR, Dawson DV, et al. Antibacterial activity of sphingoid bases and fatty acids against Gram-positive and Gram-negative bacteria. Antimicrob Agents Chemother. 2012 Mar;56(3):1157-61. PMID: 22155833.
Huang Y, Zhang XY, Chen HL. Regulation of Phospholipase D Activity in Human Hepatocacinoma Cells by Protein Kinases and D-sphingosine. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 1999;31(5):572-576. PMID: 12114973.
