D-Naproxen
Naproxen is a propionic non-steroidal anti-inflammatory drug (NSAID) that exhibits antipyretic, analgesic, anti-inflammatory, and antiviral activities. Naproxen inhibits COX-1 and COX-2 and is clinically used to treat fever, swelling, and pain. In vitro, naproxen inhibits influenza virus infection through binding of the nucleoprotein and preventing initiation of transcription and replication.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18855611
| Cas No. |
22204-53-1 |
|---|---|
| Purity |
≥98% |
| Formula |
C14H14O3 |
| Formula Wt. |
230.26 |
| Chemical Name |
S(+)6-Methoxy-α methyl-2-naphthaleneacetic acid |
| IUPAC Name |
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid |
| Synonym |
S-Naproxen, Nonyl; Equiproxen; Napren; Pranoxen |
| Melting Point |
155-158°C |
| Solubility |
Soluble in ethanol and acetone. Insoluble in water. |
| Appearance |
White or Almost White Crystalline Powder |
Lejal N, Tarus B, Bouguyon E, et al. Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus. Antimicrob Agents Chemother. 2013 May;57(5):2231-42. PMID: 23459490.
Duggan KC, Walters MJ, Musee J, et al. Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J Biol Chem. 2010 Nov 5;285(45):34950-9. PMID: 20810665.
