D,L-Tetrahydropalmatine
D,L-Tetrahydropalmatine is an alkaloid found in Corydalis and Stephania that exhibits analgesic, antinociceptive, anxiolytic, antidepressant, and anti-parasitic activities. This compound inhibits D1/2 receptors and may also inhibit L-type Ca2+ channels and some K+ channels. D,L-Tetrahydropalmatine decreases anxiety measures in the elevated plus maze and alters thresholds in assays of thermal, mechanical, and chemical pain. D,L-Tetrahydropalmatine also inhibits growth of Plasmodium.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18855807
| Cas No. |
10097-84-4 |
|---|---|
| Purity |
≥98% |
| Formula |
C21H25NO4 |
| Formula Wt. |
355.43 |
| Chemical Name |
5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H- dibenzo[a,g]quinolizine |
| IUPAC Name |
(13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline |
| Synonym |
Tetrahydropalmatine; Hynndarin |
| Melting Point |
148-149°C |
| Appearance |
White crystalline |
Baghdikian B, Mahiou-Leddet V, Bory S, et al. New antiplasmodial alkaloids from Stephania rotunda. J Ethnopharmacol. 2013 Jan 9;145(1):381-5. PMID: 23127648.
Cao FL, Shang GW, Wang Y, et al. Antinociceptive effects of intragastric DL-tetrahydropalmatine on visceral and somatic persistent nociception and pain hypersensitivity in rats. Pharmacol Biochem Behav. 2011 Nov;100(1):199-204. PMID: 21889526.
Henkes H, Franz M, Kendall O, et al. Evaluation of the anxiolytic properties of tetrahydropalmatine, a Corydalis yanhusuo compound, in the male Sprague-Dawley rat. AANA J. 2011 Aug;79(4 Suppl):S75-80. PMID: 22403971.
