D,L-Naproxen
Naproxen is a propionic non-steroidal anti-inflammatory drug (NSAID) that exhibits antipyretic, analgesic, anti-inflammatory, and antiviral activities. Naproxen inhibits COX-1 and COX-2 and is clinically used to treat fever, swelling, and pain. In vitro, naproxen inhibits influenza virus infection through binding of the nucleoprotein and preventing initiation of transcription and replication.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18855701
| Purity |
≥96% |
|---|---|
| Formula |
C14H14O3 |
| Formula Wt. |
230.26 |
| Chemical Name |
(+)-(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid |
| Synonym |
Artagen; Danaprox; Nafasol; Sutolin |
| Melting Point |
152-154°C |
| Solubility |
Insoluble in water. Soluble in acetone or ethanol. |
| Appearance |
White Crystal Powder |
Lejal N, Tarus B, Bouguyon E, et al. Structure-based discovery of the novel antiviral properties of naproxen against the nucleoprotein of influenza A virus. Antimicrob Agents Chemother. 2013 May;57(5):2231-42. PMID: 23459490.
Duggan KC, Walters MJ, Musee J, et al. Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen. J Biol Chem. 2010 Nov 5;285(45):34950-9. PMID: 20810665.
