Cytisine
Cytisine is an alkaloid originally found in Laburnum, Cytisus, and other Fabaceae-family plants. Cytisine exhibits antidepressant activity in vivo and activates nicotinic acetylcholine receptors (nAChRs), acting as a partial agonist at α4β2 nAChRs and a full agonist at α3β4 nAChRs. Cytisine is structurally similar to nicotine and shows some clinical benefit in increasing smoking cessation rates.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18854869
| Cas No. |
485-35-8 |
|---|---|
| Purity |
≥98% |
| Formula |
C11H14N2O |
| Formula Wt. |
190.24 |
| Synonym |
(-)-Cytisine |
| Melting Point |
154-156°C |
| Appearance |
White Crystal Powder |
Hajek P, McRobbie H, Myers K. Efficacy of cytisine in helping smokers quit: systematic review and meta-analysis. Thorax. 2013 Nov;68(11):1037-42. PMID: 23404838.
Simeonova R, Vitcheva V, Mitcheva M. Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats. Interdiscip Toxicol. 2010 Mar;3(1):21-5. PMID: 21217867.
Mineur YS, Somenzi O, Picciotto MR. Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice. Neuropharmacology. 2007 Apr;52(5):1256-62. PMID: 17320916.
