Cycloheximide
Cycloheximide was initially produced by Streptomyces. Cycloheximide inhibits protein synthesis in eukaryotes by preventing tRNA translocation and elongation. Cycloheximide is not used in humans due to its high toxicity. In research models, cycloheximide is used to determine protein lifespan and ribosomal profiling.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18854372
| Cas No. |
66-81-9 |
|---|---|
| Purity |
≥95% |
| Formula |
C15H23NO4 |
| Formula Wt. |
281.35 |
| Chemical Name |
[1S-[1αS*),3α,5β]]-4-[2-(3,5-Dimethyl-2-oxocyclo- hexyl)-2-hydroxyethyl]-2,6-piperidinedione |
| IUPAC Name |
4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]piperidine-2,6-dione |
| Synonym |
Naramycin A; Actidione |
| Melting Point |
119.5-121°C |
| Solubility |
Soluble in chloroform, DMSO, acetone, methanol, or ethanol. Soluble in water to 20 mg/ml. |
| Appearance |
White to off white powder |
Bohnert M, Scherer O, Wiechmann K, et al. Melleolides induce rapid cell death in human primary monocytes and cancer cells. Bioorg Med Chem. 2014 Aug 1;22(15):3856-61. PMID: 25028062.
Ren Y, DAmbrosio MA, Garvin JL, et al. Aldosterone sensitizes connecting tubule glomerular feedback via the aldosterone receptor GPR30. Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F427-34. PMID: 24966088.
Greenberger NJ, Ruppert RD. Inhibition of protein synthesis: a mechanism for the production of impaired iron absorption. Science. 1966 Jul 15;153(3733):315-6. PMID: 17780009.
