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Colchicine

Colchicine is an anti-inflammatory anti-mitotic compound originally found in Colchicum; it is clinically used to treat gout. Colchicine binds tubulin and inhibits microtubule polymerization, inhibiting inflammasome activation, cytokine generation, and chemotaxis. Colchicine inhibits neutrophil motility. The anticancer potential of colchicine is limited by its high toxicity.

References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/18853217

Cas No.

64-86-8

Purity

≥97%

Formula

C22H25NO6

Formula Wt.

399.44

Chemical Name

N-[(7S)-5,6,7,9-Tetrahydro-1,10,3,10-tetramethoxy-9- oxobenzo[a]heptalen-7-yl]acetamide

IUPAC Name

N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

Melting Point

142-150°C

Solubility

Soluble in water (40 mg/mL), ethanol (7 mg/ml), DMSO (14 mg/ml), or chloroform. Insoluble in petr. ether.

Appearance

Faintly yellow crystal powder

Dalbeth N, Lauterio TJ, Wolfe HR. Mechanism of Action of Colchicine in the Treatment of Gout. Clin Ther. 2014 Aug 21. [Epub ahead of print]. PMID: 25151572.

Ching JK, Ju JS, Pittman SK, et al. Increased autophagy accelerates colchicine-induced muscle toxicity. Autophagy. 2013 Dec;9(12):2115-25. PMID: 24184927.

3,5-CQA