Cinnarizine
Cinnarizine is an inhibitor of L-type voltage-gated Ca2+ channels that is clinically used to treat migraine and vertigo. Cinnarizine exhibits anticonvulsant/antiepileptic activity in combination with other therapies in animal models. This compound also inhibits D2 receptors, suppressing stimulant-induced locomotor activity, and acts as a functional inhibitor of acid sphingomyelinase (FIASMA).
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18852009
| Cas No. |
298-57-7 |
|---|---|
| Purity |
≥98% |
| Formula |
C26H28N2 |
| Formula Wt. |
368.51 |
| Chemical Name |
1-benzhydryl-4-cinnamyl-piperazine |
| IUPAC Name |
1-benzhydryl-4-[(E)-3-phenylprop-2-enyl]piperazine |
| Synonym |
Aplactan; Aplexal; Apotomin; Artate; Carecin; Cerebolan; 1-trans-Cinnamyl-4-diphenylmethylpiperazine |
| Melting Point |
118-122°C |
| Solubility |
Practically insoluble in water. Soluble in dichloromethane or ether. Slightly soluble in methanol. |
| Appearance |
White or Almost-White Crystal Powder |
Taghdiri F, Togha M, Razeghi Jahromi S, et al. Cinnarizine for the prophylaxis of migraine associated vertigo: a retrospective study. Springerplus. 2014 May 7;3:231. PMID: 24834377.
Brahmane RI, Wanmali VV, Pathak SS, et al. Role of cinnarizine and nifedipine on anticonvulsant effect of sodium valproate and carbamazepine in maximal electroshock and pentylenetetrazole model of seizures in mice. J Pharmacol Pharmacother. 2010 Jul;1(2):78-81. PMID: 21350614.
DallIgna OP, Tort AB, Souza DO, et al. Cinnarizine has an atypical antipsychotic profile in animal models of psychosis. J Psychopharmacol. 2005 Jul;19(4):342-6. PMID: 15982988.
