Cimetidine
Cimetidine is an antihistamine that inhibits H2 histamine receptors, exhibiting antacid and anticancer chemotherapeutic activities. Cimetidine inhibits catalase activity and also acts as an antagonist at androgen receptors. Cimetidine increases the efficacy of chemotherapeutic compounds when administered concurrently; in animal models of lung cancer, it increases expression of IFN-γ and Fas, inhibiting tumor growth.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18851965
| Cas No. |
51481-61-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C10H16N6S |
| Formula Wt. |
252.34 |
| Chemical Name |
N-Cyano-N-methyl-N-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine |
| IUPAC Name |
1-cyano-2-methyl-3-[2-[(5-methyl-1H-imidazol-4-yl)methylsulfanyl]ethyl]guanidine |
| Synonym |
Acibilin; Acinil; Cimetag; Edalene; Eureceptor; Gastromet; Peptol; Ulcerfen; Ulcomet |
| Melting Point |
141-143°C |
| Solubility |
Soluble in water at 37oC. |
| Appearance |
A White or Almost White Crystalline Powder |
Masoud M, Ebrahimi F, Minai-Tehrani D. Effect of Cimetidine on Catalase Activity of Pseudomonas aeruginosa: A Suggested Mechanism of Action. J Mol Microbiol Biotechnol. 2014 Jul 2;24(3):196-201. PMID: 24993120.
Zheng Y, Xu M, Li X, et al. Cimetidine suppresses lung tumor growth in mice through proapoptosis of myeloid-derived suppressor cells. Mol Immunol. 2013 May;54(1):74-83. PMID: 23220070.
Matsumoto S, Imaeda Y, Umemoto S, et al. Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells. Br J Cancer. 2002 Jan 21;86(2):161-7. PMID: 11870500.
Richards DA. Comparative pharmacodynamics and pharmacokinetics of cimetidine and ranitidine. J Clin Gastroenterol. 1983;5 Suppl 1:81-90. PMID: 6317740.
