Cheirolin
Cheirolin is an isothiocyanate (ITC) that exhibits antioxidative activity. Cheirolin is a sulfonyl analog of iberin. Like others ITCs, cheirolin induces phase II enzymes. In vitro, cheirolin increases activation and expression of Nrf2 as well as expression of heme oxygenase 1 (HO-1) and γ-glutamylcysteine synthetase.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18849381
| Cas No. |
505-34-0 |
|---|---|
| Purity |
≥97% |
| Formula |
C5H9NO2S2 |
| Formula Wt. |
179.26 |
| Chemical Name |
1-Isothiocyanato-3-(methylsulfonyl)-propane |
| IUPAC Name |
1-isothiocyanato-3-methylsulfonylpropane |
| Melting Point |
47.5°C |
| Solubility |
Slightly soluble in water, ether; freely soluble in alcohol, chloroform, ethyl acetate. |
| Appearance |
White Crystal Powder |
Ernst IM, Palani K, Esatbeyoglu T, et al. Synthesis and Nrf2-inducing activity of the isothiocyanates iberverin, iberin and cheirolin. Pharmacol Res. 2013 Apr;70(1):155-62. PMID: 23403058.
