Chartreusin
Chartreusin is an antibiotic compound that also exhibits anticancer activity. Chartreusin binds GC-rich DNA sequences, inhibiting synthesis of RNA and causing free radical accumulation.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18849352
| Cas No. |
6377-18-0 |
|---|---|
| Purity |
≥98% |
| Formula |
C32H32O14 |
| Formula Wt. |
640.6 |
| Chemical Name |
Benzo(h)(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,12-dione, 10-((6-deoxy-2-O-(6-deoxy-3-O-methyl-alpha-D-galactopyranosyl)-beta-D-galactopyranosyl)oxy)-6-hydroxy-1-methyl- (9CI) |
| Synonym |
Lambdamycin; NSC-5159. |
| Melting Point |
184-186°C |
| Solubility |
Soluble in acetone. Practically insoluble in water. |
| Appearance |
Yellow sold |
Portugal J. Chartreusin, elsamicin A and related anti-cancer antibiotics. Curr Med Chem Anticancer Agents. 2003 Nov;3(6):411-20. PMID: 14529449.
Uramoto M, Kusano T, Nishio T, et al. Specific binding of chartreusin, an antitumor antibiotic, to DNA. FEBS Lett. 1983 Mar 21;153(2):325-8. PMID: 6311618.
Yagi M, Nishimura T, Suzuki H, et al. Chartreusin, an antitumor glycoside antibiotic, induces DNA strand scission. Biochem Biophys Res Commun. 1981 Feb 12;98(3):642-7. PMID: 7225117.
