Cephalomannine
Cephalomannine is a diterpene found in Taxus that exhibits anticancer and nephroprotective activities. Cephalomannine may display anticancer activity through binding of tubulin although current research is limited. This compound suppresses cell growth of neuroblastoma and glioblastoma cells and inhibits activity of DNA polymerase. In animal models of polycystic kidney disease, cephalomannine promotes microtubule assembly and increases survival rates.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18848909
| Cas No. |
71610-00-9 |
|---|---|
| Purity |
≥94% |
| Formula |
C45H53NO14 |
| Formula Wt. |
831.91 |
| Synonym |
Taxol B |
| Solubility |
Soluble in DMSO. |
| Appearance |
White Powder |
Li Y, Qin F, Wang SM, et al. Chemical studies on Taxus canadensis. Chem Biodivers. 2013 Oct;10(10):1729-53. PMID: 24130020.
Oshige M, Takenouchi M, Kato Y, et al. Taxol derivatives are selective inhibitors of DNA polymerase alpha. Bioorg Med Chem. 2004 May 15;12(10):2597-601. PMID: 15110841.
Woo DD, Tabancay AP Jr, Wang CJ. Microtubule active taxanes inhibit polycystic kidney disease progression in cpk mice. Kidney Int. 1997 May;51(5):1613-8. PMID: 9150481.
Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9. PMID: 21573554.
