Canrenone
Canrenone is an active metabolite of spironolactone that acts as an aldosterone antagonist, anti-androgen, and diuretic. Canrenone acts as a partial agonist on the Na+/K+ ATPase.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1884802
| Cas No. |
976-71-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C22H28O3 |
| Formula Wt. |
340.46 |
| Chemical Name |
(17α)-17-Hydroxy-3-oxo-pregna-4,6-diene-21- carboxylic acid γ-lactone |
| IUPAC Name |
10,13-dimethylspiro[2,8,9,11,12,14,15,16-octahydro-1H-cyclopenta[a]phenanthrene-17,5-oxolane]-2,3-dione |
| Synonym |
Phanurane |
| Melting Point |
149-151°C |
| Appearance |
Light yellow crystal powder |
Cargnelli G, Trevisi L, Debetto P, et al. Effects of canrenone on aorta and right ventricle of the rat. J Cardiovasc Pharmacol. 2001 May;37(5):540-7. PMID: 11336105.
Corvol P, Claire M, Oblin ME, et al. Mechanism of the antimineralocorticoid effects of spirolactones. Kidney Int. 1981 Jul;20(1):1-6. PMID: 7029118.
