CREBtide
CREBtide is a synthetic spliced variant of C-terminal response element binding protein CREB. CREBtide is a substrate of protein kinase D1 (PKD1) and PKA.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18853835
| Purity |
≥95% |
|---|---|
| Formula |
C73H127N29O18 |
| Formula Wt. |
1699.01 |
| IUPAC Name |
(4S)-5-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-4-(diaminomethylideneamino)butyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoic acid |
Rybin VO, Guo J, Harleton E, et al. Regulatory domain determinants that control PKD1 activity. J Biol Chem. 2012 Jun 29;287(27):22609-15. PMID: 22582392.
Colbran JL, Roach PJ, Fiol CJ, et al. cAMP-dependent protein kinase, but not the cGMP-dependent enzyme, rapidly phosphorylates delta-CREB, and a synthetic delta-CREB peptide. Biochem Cell Biol. 1992 Oct-Nov;70(10-11):1277-82. PMID: 1338414.
