CK-636
CK-636 is an inhibitor of actin-related protein 2/3 (Arp2/3); it binds between Arp2 and Arp3 to prevent the association of the two into their active conformation, limiting the formation of lamellipodia and cellular movement. CK-636 inhibits the production of tight junctions, cell-cell adhesion, and epidermal differentiation in vitro. This compound is used to study cellular movement and path finding in vitro.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18852342
| Cas No. |
442632-72-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C16H16N2OS |
| Formula Wt. |
284.38 |
| IUPAC Name |
N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide |
| Synonym |
CK636, CK-0944636 |
Zhou K, Muroyama A, Underwood J, et al. Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3820-9. PMID: 24043783.
Kwon KW, Park H, Doh J. Migration of T cells on surfaces containing complex nanotopography. PLoS One. 2013 Sep 12;8(9):e73960. PMID: 24069255.
Nolen BJ, Tomasevic N, Russell A, et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature. 2009 Aug 20;460(7258):1031-4. PMID: 19648907.
