Bisacodyl
Bisacodyl is a diphenylmethane derivative that exhibits gastrointestinal motility modulating (laxative) activity. Bisacodyl activates macrophages, activating PKC, increasing PGE2 secretion, and downregulating expression of aquaporin 3 channels; it may also inhibit the Na+/K+ ATPase. As a result of these actions, colonic fluid and NaCl secretion is increased. Bisacodyl also stimulates enteric nerves, increasing contractions.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18844710
| Cas No. |
603-50-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C22H19NO4 |
| Formula Wt. |
361.39 |
| Chemical Name |
4,4-(2-Pyridylmethylene)-bisphenol diacetate |
| IUPAC Name |
[4-[(4-acetyloxyphenyl)-pyridin-2-ylmethyl]phenyl] acetate |
| Synonym |
Bicol; Broxalax; Contalax; DAMP; Dulrolax; Endokolat; Laxadin; Laxorex; Perilax; Telemin; Ulcolax |
| Melting Point |
138°C |
| Solubility |
Soluble in acids, acetone, propylene glycol and other organic solvents. Ethanol (4.5 mg/mL). Practically insoluble in water and alkaline solutions. |
| Appearance |
White Crystal Powder |
Ikarashi N, Baba K, Ushiki T, et al. The laxative effect of bisacodyl is attributable to decreased aquaporin-3 expression in the colon induced by increased PGE2 secretion from macrophages. Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G887-95.PMID: 21868635.
Manabe N, Cremonini F, Camilleri M, et al. Effects of bisacodyl on ascending colon emptying and overall colonic transit in healthy volunteers. Aliment Pharmacol Ther. 2009 Nov 1;30(9):930-6. PMID: 19678812.
Beubler E, Schirgi-Degen A. Stimulation of enterocyte protein kinase C by laxatives in-vitro. J Pharm Pharmacol. 1993 Jan;45(1):59-62. PMID: 8094448.
