Biotin
Biotin is a water-soluble B vitamin (vitamin B7) that may be found in many foods but is also administered as a dietary supplement. Biotin is a coenzyme involved in the synthesis of fatty acids, isoleucine, and valine; it also plays a role in gluconeogenesis. Biotin may be found attached to lysine residues on histones, modulating genetic regulation. Biotin conjugates are used to study the binding of small, bioactive molecules to endogenous substrates.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18844328
| Cas No. |
58-85-5 |
|---|---|
| Purity |
≥98% |
| Formula |
C10H16N2O3S |
| Formula Wt. |
244.31 |
| Chemical Name |
Hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanoic acid |
| IUPAC Name |
5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoic acid |
| Synonym |
Biodermatin; Coenzyme R; Vitamin H |
| Melting Point |
232-233°C |
| Solubility |
Soluble in water (0.2 mg/mL). Very soluble in hot water and dilute alkali. Insoluble in common organic solvents. DMSO to 49 mg/mL. 2 M NaOH to 50 mg/mL. |
| Appearance |
A White or off-White Crystalline Powder |
Lietzan AD, St Maurice M. Functionally diverse biotin-dependent enzymes with oxaloacetate decarboxylase activity. Arch Biochem Biophys. 2014 Feb 15;544:75-86. PMID: 24184447.
Trippier PC. Synthetic strategies for the biotinylation of bioactive small molecules. ChemMedChem. 2013 Feb;8(2):190-203. PMID: 23303486.
Zempleni J, Wijeratne SS, Hassan YI. Biotin. Biofactors. 2009 Jan-Feb;35(1):36-46. PMID: 19319844.
