Betamethasone
Betamethasone is a glucocorticoid receptor agonist that exhibits anti-inflammatory, immunosuppressive, and anti-ulcerative activities. Betamethasone is clinically used to treat skin irritations such as psoriasis and to accelerate preterm fetal lung development.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18843668
| Cas No. |
378-44-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C22H29FO5 |
| Formula Wt. |
392.46 |
| Chemical Name |
(11β,16β)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione |
| IUPAC Name |
(8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one |
| Synonym |
Becort; Betnelan; Celestene; Dermabet; Diprolene; Visubeta |
| Melting Point |
231-234°C (dec.) |
| Solubility |
Insoluble in water, ethanol (15 mg/mL). |
| Appearance |
White Crystal Powder |
Shepherd J, Taheri A, Feldman SR. Once-daily topical treatment for psoriasis: calcipotriene + betamethasone two-compound topical formulation. Clin Cosmet Investig Dermatol. 2013 Dec 19;7:19-22. PMID: 24379688.
Waffarn F, Davis EP. Effects of antenatal corticosteroids on the hypothalamic-pituitary-adrenocortical axis of the fetus and newborn: experimental findings and clinical considerations. Am J Obstet Gynecol. 2012 Dec;207(6):446-54. PMID: 22840973.
