Bergenin
Bergenin is a trihydroxybenzoic acid glycoside found in Bergenia and other plant sources. Bergenin exhibits immunosuppressive, anti-inflammatory, anti-parasitic, antimalarial, analgesic, antinociceptive, antioxidative, anti-diabetic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities. In vivo, bergenin downregulates expression of NF-κB and IKKβ, decreases IgG levels, cytokine release, and other immune response mediators, and suppresses development of edema. In vitro and in vivo, bergenin inhibits growth of Plasmodium. In other animal models, this compound inhibits mechanical hyperalgesia. In diabetic rats, bergenin decreases levels of blood glucose, total cholesterol, and LDL and increases levels of HDL, superoxide dismutase, and catalase. Additionally, bergenin inhibits tumor development induced by TPA and DMBA.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18843652
| Cas No. |
477-90-7 |
|---|---|
| Purity |
≥98% |
| Formula |
C14H16O9 |
| Formula Wt. |
328.27 |
| IUPAC Name |
3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one;hydrate |
| Melting Point |
237-240°C |
| Solubility |
Soluble in water. |
| Appearance |
White Powder |
Jain SK, Singh S, Khajuria A, et al. Pyrano-isochromanones as IL-6 Inhibitors: Synthesis, in Vitro and in Vivo Antiarthritic Activity. J Med Chem. 2014 Aug 28;57(16):7085-97. PMID: 25111439.
Liang J, Li Y, Liu X, et al. In vivo and in vitro antimalarial activity of bergenin. Biomed Rep. 2014 Mar;2(2):260-264. PMID: 24649107.
Zhang J, Nishimoto Y, Tokuda H, et al. Cancer chemopreventive effect of bergenin from Peltophorum pterocarpum wood. Chem Biodivers. 2013 Oct;10(10):1866-75. PMID: 24130029.
Kumar R, Patel DK, Prasad SK, et al. Type 2 antidiabetic activity of bergenin from the roots of Caesalpinia digyna Rottler. Fitoterapia. 2012 Mar;83(2):395-401. PMID: 22178680.
de Oliveira CM, Nonato FR, de Lima FO, et al. Antinociceptive properties of bergenin. J Nat Prod. 2011 Oct 28;74(10):2062-8. Erratum in: J Nat Prod. 2012 Feb 24;75(2):305. PMID: 21939182.
Wang X, Tang S, Zhai H, et al. Studies on anti-tumor metastatic constituents from Ardisia Crenata. Zhongguo Zhong Yao Za Zhi. 2011 Apr;36(7):881-5. PMID: 21761727.
