Baicalin
Baicalin is a flavone found in Scutellaria that exhibits antiviral, antioxidative, antihypertensive, cardioprotective, anti-inflammatory, and anticancer chemotherapeutic activities. Baicalin inhibits prolyl oligopeptidase. Baicalin also inhibits neuraminidase, preventing influenza infection. In animal models of hypoxia-induced pulmonary arterial hypertension, baicalin decreases systolic blood pressure, inhibits ventricular remodeling, and suppresses proliferation of pulmonary artery smooth muscle cells. In animal models of cerebral hemorrhage, baicalin decreases development of edema and suppresses expression of matrix metalloproteinase 9 (MMP9), IL-6, and IL-1β. Additionally, baicalin inhibits UV-induced skin aging responses in fibroblasts and inhibits cell and tumor growth in models of acute myelogenous leukemia (AML).
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18842982
| Cas No. |
21967-41-9 |
|---|---|
| Purity |
≥95% |
| Formula |
C21H18O11 |
| Formula Wt. |
446.36 |
| IUPAC Name |
(2S,3S,4S,5R,6S)-6-(5,6-dihydroxy-4-oxo-2-phenylchromen-7-yl)oxy-3,4,5-trihydroxyoxane-2-carboxylic acid |
| Synonym |
7-D-Glucuronic acid-5,6-dihydroxyflavone |
| Melting Point |
202-205°C (lit.) |
| Solubility |
Soluble in DMSO or ethanol. |
| Appearance |
Yellow Powder |
Ding Y, Dou J, Teng Z, et al. Antiviral activity of baicalin against influenza A (H1N1/H3N2) virus in cell culture and in mice and its inhibition of neuraminidase. Arch Virol. 2014 Jul 31. [Epub ahead of print]. PMID: 25078390.
Min W, Liu X, Qian Q, et al. The effects of baicalin against UVA-induced photoaging in skin fibroblasts. Am J Chin Med. 2014;42(3):709-27. PMID: 24871661.
Zhang L, Pu Z, Wang J, et al. Baicalin inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation via the AKT/HIF-1α/p27-associated pathway. Int J Mol Sci. 2014 May 9;15(5):8153-68. PMID: 24821539.
Zhou QB, Jin YL, Jia Q, et al. Baicalin attenuates brain edema in a rat model of intracerebral hemorrhage. Inflammation. 2014 Feb;37(1):107-15. PMID: 23974988.
Zheng J, Hu JD, Huang Y, et al. Effects of baicalin on HL-60 cell xenografts in nude mice and its mechanism. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2012 Oct;20(5):1066-71. PMID: 23114120.
Tarragó T, Kichik N, Claasen B, et al. Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor. Bioorg Med Chem. 2008 Aug 1;16(15):7516-24. PMID: 18650094.
