Bactenecin
Bactenecin is a cathelicidin-derived antimicrobial peptide (AMP) found in bovine neutrophils. Bactenecin exhibits antibiotic activity, increasing membrane permeability and inhibiting growth. Bactenecin is an effective antibacterial peptide, displaying activity against Burkholderia, Escherichia, Pseudomonas, Salmonella, Staphylococcus, and Enterobacter.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18842921/
| Cas No. |
116229-36-8 |
|---|---|
| Purity |
≥95% |
| Formula |
C63H118N24O13S2 |
| Formula Wt. |
1483.90 |
| IUPAC Name |
2-[[28-[[2-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-4-methylpentanoyl]amino]-13,22-di(butan-2-yl)-10,25-bis[3-(diaminomethylideneamino)propyl]-6,9,12,15,18,21,24,27-octaoxo-7,16,19-tri(propan-2-yl)-1,2-dithia-5,8,11,14,17,20,23,26-octazacyclononacosane-4-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid |
| Synonym |
Arg-leu-cyclo(cys-arg-ile-val-val-ile-arg-val-cys)-arg; Bac7 |
| Appearance |
White to off white powder |
Madhongsa K, Pasan S, Phophetleb O, et al. Antimicrobial action of the cyclic peptide bactenecin on Burkholderia pseudomallei correlates with efficient membrane permeabilization. PLoS Negl Trop Dis. 2013 Jun 13;7(6):e2267. PMID: 23785532.
Lee JY, Yang ST, Lee SK, et al. Salt-resistant homodimeric bactenecin, a cathelicidin-derived antimicrobial peptide. FEBS J. 2008 Aug;275(15):3911-20. PMID: 18616463.
Wu M, Hancock RE. Interaction of the cyclic antimicrobial cationic peptide bactenecin with the outer and cytoplasmic membrane. J Biol Chem. 1999 Jan 1;274(1):29-35. PMID: 9867806.
