Artemether
Artemether is a sesquiterpene lactone derived from Artemisia. Artemisinins such as artemether are best known for their antimalarial activity. Artemether exhibits anti-parasitic activity against Plasmodium, Leishmania, and Schistosoma.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18842623
| Cas No. |
71963-77-4 |
|---|---|
| Purity |
≥98% |
| Formula |
C16H26O5 |
| Formula Wt. |
298.37 |
| Chemical Name |
(3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin |
| Synonym |
Dihydroartemisinin methyl ether; Dihydroqinghaosu methyl ether; Paluther |
| Melting Point |
86-88°C |
| Solubility |
Insoluble in water. Soluble in acetone and ethyl acetate. |
| Appearance |
White Crystal Powder |
Angus B. Novel anti-malarial combinations and their toxicity. Expert Rev Clin Pharmacol. 2014 May;7(3):299-316. PMID: 24716844.
Wang W, Li TY, Ji Y, et al. Efficacy of artemether and artesunate in mice infected with praziquantel non-susceptible isolate of Schistosoma japonicum. Parasitol Res. 2014 Mar;113(3):925-31. PMID: 24326467.
Ebrahimisadr P, Ghaffarifar F, Mohammad Hassan Z. In-vitro Evaluation of Antileishmanial Activity and Toxicity of Artemether with Focus on its Apoptotic Effect. Iran J Pharm Res. 2013 Fall;12(4):903-9. PMID: 24523770.
