Aripiprazole
Aripiprazole is a second generation atypical antipsychotic that also exhibits neuromodulatory, antidepressant, anxiolytic, antipsychotic, cognition enhancing, and antioxidative activities. Aripiprazole acts as a partial agonist at D2 receptors and 5-HT1A receptors and as an antagonist at 5-HT2A receptors and is used clinically to treat schizophrenia and bipolar I disorder. Aripiprazole also displays moderate affinity for and 5-HT2C/6/7 receptors and the serotonin transporter (SERT). Aripiprazole improves spatial memory in the Morris water maze test, exhibits antidepressant activity in the Porsolt test, and also improves social competence, potentially through increases in GABA transmission in prefrontal brain regions. This compound also potentiates nerve growth factor (NGF)-induced neurite outgrowth and increases levels of heat shock protein 90α (HSP90α). Aripiprazole protects cells from hydrogen peroxide-induced damage, increasing activity of superoxide dismutase 1 (SOD1).
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18842366
| Cas No. |
129722-12-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C23H27Cl2N3O2 |
| Formula Wt. |
448.39 |
| Chemical Name |
7-[4-[4-(2,3-dichorophenyl)piperazin-1-yl]butoxy]-1, 2, 3, 4-tetrahydroquinolin-2-one |
| IUPAC Name |
7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one |
| Melting Point |
139-139.5°C |
| Appearance |
White to off white powder |
Lee JS, Lee JD, Park HJ, et al. Is the GABA System Related to the Social Competence Improvement Effect of Aripiprazole? An (18)F-Fluoroflumazenil PET Study. Psychiatry Investig. 2013 Mar;10(1):75-80. PMID: 23482902.
Miljević Č, Nikolić-Kokić A, Nikolić M, et al. Effect of atypical antipsychotics on antioxidant enzyme activities in human erythrocytes (in vitro study). Hum Psychopharmacol. 2013 Jan;28(1):1-6. PMID: 23124725.
Ishima T, Iyo M, Hashimoto K. Neurite outgrowth mediated by the heat shock protein Hsp90α: a novel target for the antipsychotic drug aripiprazole. Transl Psychiatry. 2012 Oct 16;2:e170. PMID: 23047241.
Zupancic M, Gonzalez ML. Aripiprazole in the acute and maintenance phase of bipolar I disorder. Ther Clin Risk Manag. 2012;8:1-6. PMID: 22298948.
Burda K, Czubak A, Kus K, et al. Influence of aripiprazole on the antidepressant, anxiolytic and cognitive functions of rats. Pharmacol Rep. 2011;63(4):898-907. PMID: 22001977.
Stark AD, Jordan S, Allers KA, et al. Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT 2A receptors: functional receptor-binding and in vivo electrophysiological studies. Psychopharmacology (Berl). 2007 Feb;190(3):373-82. PMID: 17242925.
