Argatroban
Argatroban is an antithrombotic/anticoagulant compound that inhibits thrombin. Argatroban is clinically used to treat thrombosis and acute coronary syndrome.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18842294
| Cas No. |
74863-84-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C23H36N6O5S |
| Formula Wt. |
508.64 |
| Chemical Name |
(2R,4R)-4-Methyl-1-((S)-N(sup2)-(((RS)-1,2,3,4- tetrahydro-3-methyl-8-quinolyl)sulfonyl)arginyl)- pipecolic acid |
| IUPAC Name |
(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]pentanoyl]-4-methylpiperidine-2-carboxylic acid |
| Synonym |
Argatrobanum |
| Melting Point |
188-191°C |
| Solubility |
Soluble in ethanol. |
| Appearance |
White Crystalline Powder |
Tardy-Poncet B, Combe M, Piot M, et al. Effects of argatroban, danaparoid, and fondaparinux on trombin generation in heparin-induced thrombocytopenia. Thromb Haemost. 2013 Mar;109(3):504-9. PMID: 23328916.
Cruz-González I, López-Jiménez R, Perez-Rivera A, et al. Pharmacokinetic evaluation of argatroban for the treatment of acute coronary syndrome. Expert Opin Drug Metab Toxicol. 2012 Nov;8(11):1483-93. PMID: 22970706.
