Aprotinin
Aprotinin is a polypeptide that exhibits anti-fibrinolytic (pro-coagulant) activity. Aprotinin inhibits serine proteases such as trypsin, chymotrypsin, plasmin, and kallikrein. Inhibiting these proteases prevents formation of Factor XIIa and prevents breakdown of blood clots. Aprotinin is clinically used during surgeries to prevent bleeding.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18842067
| Cas No. |
9087-70-1 |
|---|---|
| Purity |
≥98% |
| Formula |
C284H432N84O79S7 |
| Formula Wt. |
6511.44 |
| Synonym |
Pancreatic trypsin inhibitor; Antagosan; Fosten; Iniprol; Repulson; Trazinin; Zymofren |
| Solubility |
Soluble in water (10 mg/ml). |
| Appearance |
White to light yellow powder |
Shiga T, Wajima Z, Inoue T, et al. Aprotinin in major orthopedic surgery: a systematic review of randomized controlled trials. Anesth Analg. 2005 Dec;101(6):1602-7. PMID: 16301226.
Mahdy AM, Webster NR. Perioperative systemic haemostatic agents. Br J Anaesth. 2004 Dec;93(6):842-58. PMID: 15277296.
Kassell B, Laskowski M Sr. The basic trypsin inhibitor of bovine pancreas. V. The disulfide linkages. Biochem Biophys Res Commun. 1965 Aug 16;20(4):463-8. PMID: 5860161.
