Ampiroxicam
Ampiroxicam is a non-steroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory and analgesic activities; it inhibits COX-1 and COX-2. Ampiroxicam is a prodrug of piroxicam that does not inhibit prostaglandin synthesis itself. In animal models of inflammation, ampiroxicam decreases paw edema.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18838413
| Cas No. |
99464-64-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C20H21N3O7S |
| Formula Wt. |
447.46 |
| Chemical Name |
Carbonic acid ethyl 1-[[2-methyl-3-[(2-pyridinyl- amino)carbonyl]-2H-1,2-benzothiazin-4-yl]oxy]ethyl ester S,S-dioxide |
| IUPAC Name |
ethyl1-[[2-methyl-1,1-dioxo-3-(pyridin-2-ylcarbamoyl)-1λ6,2-benzothiazin-4-yl]oxy]ethyl carbonate |
| Synonym |
CP-65703; Flucam |
| Melting Point |
159-161°C |
| Solubility |
Soluble in alcohol. Insoluble in acetone. |
| Appearance |
White Crystalline Powder, Almost Odorless |
Sai S, Fujii K, Hiranuma K, et al. Preoperative ampiroxicam reduces postoperative pain after hand surgery. J Hand Surg Br. 2001 Aug;26(4):377-9. PMID: 11469844.
Carty TJ, Marfat A, Moore PF, et al. Ampiroxicam, an anti-inflammatory agent which is a prodrug of piroxicam. Agents Actions. 1993 Jul;39(3-4):157-65. PMID: 8304243.
