Amitraz
Amitraz is an agonist at α-adrenergic receptors that displays insecticide activity. Amitraz also inhibits monoamine oxidase (MAO) and synthesis of prostaglandins. Additionally, amitraz may act on octopamine receptors. Amitraz acts as an acaricide and is commonly used in veterinary prophylaxis against flea and tick infections. Amitraz may inhibit β-cell insulin release in mammals.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/1883799
| Cas No. |
33089-61-1 |
|---|---|
| Purity |
≥97% |
| Formula |
C19H23N3 |
| Formula Wt. |
293.41 |
| Chemical Name |
N-(2,4-Dimethylphenyl)-N-[[(2,4-dimethylphenyl)imino]methyl]-N-methylmethanimidamide |
| IUPAC Name |
N-(2,4-dimethylphenyl)-N-[(2,4-dimethylphenyl)iminomethyl]-N-methylmethanimidamide |
| Synonym |
Aludex; Mitaban; Mitac; Taktic; Topline |
| Melting Point |
86-87°C |
| Solubility |
Insoluble in water. Soluble in xylene and acetone. |
| Appearance |
White to Yellowish Powder |
Chen AC, He H, Davey RB. Mutations in a putative octopamine receptor gene in amitraz-resistant cattle ticks. Vet Parasitol. 2007 Sep 30;148(3-4):379-83. PMID: 17662534.
Chen TH, Hsu WH. Inhibition of insulin release by a formamidine pesticide amitraz and its metabolites in a rat beta-cell line: an action mediated by alpha-2 adrenoceptors, a GTP-binding protein and a decrease in cyclic AMP. J Pharmacol Exp Ther. 1994 Dec;271(3):1240-5. PMID: 7527851.
Costa LG, Olibet G, Murphy SD. Alpha 2-adrenoceptors as a target for formamidine pesticides: in vitro and in vivo studies in mice. Toxicol Appl Pharmacol. 1988 Apr;93(2):319-28. PMID: 2833825.
