Amisulpride
Amisulpride is an atypical antipsychotic that acts as an antagonist at 5-HT7 receptors and D2/3 receptors. Amisulpride also exhibits neuroprotective activity, modulating β2-arrestin signaling to increase phosphorylation of Akt and GSK-3β, increasing neurite outgrowth in vitro.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18837922
| Cas No. |
71675-85-9 |
|---|---|
| Purity |
≥98% |
| Formula |
C17H27N3O4S |
| Formula Wt. |
369.48 |
| IUPAC Name |
4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide |
| Melting Point |
126-127C |
| Solubility |
Ethanol (1 mg/ml), DMSO (15 mg/ml), DMF (15 mg/ml) |
| Appearance |
White to off white powder |
Meltzer HY. Serotonergic mechanisms as targets for existing and novel antipsychotics. Handb Exp Pharmacol. 2012;(212):87-124. PMID: 23129329.
Park SW, Seo MK, Cho HY, et al. Differential effects of amisulpride and haloperidol on dopamine D2 receptor-mediated signaling in SH-SY5Y cells. Neuropharmacology. 2011 Sep;61(4):761-9. PMID: 21663752.
Möller HJ. Amisulpride: limbic specificity and the mechanism of antipsychotic atypicality. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Oct;27(7):1101-11. PMID: 14642970.
