Allicin
Allicin is an thiocyanate found in garlic; it exhibits a wide variety of properties, including anticancer, antioxidative, antihypertensive, anti-arrhythmic, anti-parasitic, and anti-diabetic activities. In vitro, allicin binds cellular nucleic acid, primarily nitrogenous bases and phosphate backbones, and induces autophagy and apoptosis, leading to cell death. The cardiovascular activities of allicin stem from its ability to decrease systolic blood pressure and triglyceride levels and to shorten action potential duration through inhibition of L-type voltage-gated Ca2+ channels and activation of inward rectifying K+ channels in animal models. The antioxidative activity of allicin is shown in vitro and in vivo through its ability to enhance Nrf2 signaling, to increase superoxide dismutase and glutathione levels, and also to inhibit cyclophosphamide-induced oxidative lung damage in animal models. Additionally, allicin inhibits multiplication of intracellular Leishmania promastigotes in vitro and ex vivo and decreases anti-islet cell antibodies and insulin levels in animal models of type 1 diabetes mellitus. This product is a solution of methanol:water:formic acid (60:40:0.1) and allicin at 10mg/mL.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18837459
| Cas No. |
539-86-6 |
|---|---|
| Purity |
≥98% |
| Formula |
C6H10OS2 |
| Formula Wt. |
162.27 |
| Chemical Name |
Thio-2-propene-1-sulfinic acid S-allyl ester |
| IUPAC Name |
3-prop-2-enylsulfinylsulfanylprop-1-ene |
| Synonym |
Allylthiosulphinic acid allyl ester; Diallyl thiosulfinate |
| Melting Point |
<25°C |
| Solubility |
Soluble in water. Miscible with alcohol, ether, benzene. |
| Appearance |
Clear Liquid |
Chu YL, Ho CT, Chung JG, et al. Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy. J Agric Food Chem. 2013 Oct 16;61(41):9839-9848. PMID: 24059278.
Tyagi G, Pradhan S, Srivastava T, et al. Nucleic acid binding properties of allicin: Spectroscopic analysis and estimation of anti-tumor potential. Biochim Biophys Acta. 2013 Sep 13;1840(1):350-356. PMID: 24041991.
Liu DS, Gao W, Liang ES, et al. Effects of allicin on hyperhomocysteinemia-induced experimental vascular endothelial dysfunction. Eur J Pharmacol. 2013 Aug 15;714(1-3):163-9. PMID: 23792140.
Ashry NA, Gameil NM, Suddek GM. Modulation of cyclophosphamide-induced early lung injury by allicin. Pharm Biol. 2013 Jun;51(6):806-11. PMID: 23675840.
Elkayam A, Peleg E, Grossman E, et al. Effects of allicin on cardiovascular risk factors in spontaneously hypertensive rats. Isr Med Assoc J. 2013 Mar;15(3):170-3. PMID: 23662381.
Huang W, Wang Y, Cao YG, et al. Antiarrhythmic effects and ionic mechanisms of allicin on myocardial injury of diabetic rats induced by streptozotocin. Naunyn Schmiedebergs Arch Pharmacol. 2013 Aug;386(8):697-704. PMID: 23604291.
Osman M, Adnan A, Salmah Bakar N, et al. Allicin has significant effect on autoimmune anti-islet cell antibodies in type 1 diabetic rats. Pol J Pathol. 2012 Dec;63(4):248-54. PMID: 23359194.
Jesús Corral-Caridad M, Moreno I, Toraño A, et al. Effect of allicin on promastigotes and intracellular amastigotes of Leishmania donovani and L. infantum. Exp Parasitol. 2012 Dec;132(4):475-82. PMID: 22995646.
Li XH, Li CY, Xiang ZG, et al. Allicin ameliorates cardiac hypertrophy and fibrosis through enhancing of Nrf2 antioxidant signaling pathways. Cardiovasc Drugs Ther. 2012 Dec;26(6):457-65. PMID: 22990325.
Zhang L, Zhang H, Miao Y, et al. Protective effect of allicin against acrylamide-induced hepatocyte damage in vitro and in vivo. Food Chem Toxicol. 2012 Sep;50(9):3306-12. PMID: 22705327.
