Acyclovir
Acyclovir is a guanosine nucleoside analog that exhibits antiviral activity. Acyclovir is clinically used to treat infections of the herpes simplex virus; it inhibits viral DNA polymerase and D-amino acid oxidase.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18835882
| Cas No. |
59277-89-3 |
|---|---|
| Purity |
≥98% |
| Formula |
C8H11N5O3 |
| Formula Wt. |
225.20 |
| Chemical Name |
Acycloguanosine; Vipral; Zovirax |
| IUPAC Name |
2-amino-9-(2-hydroxyethoxymethyl)-3H-purin-6-one |
| Melting Point |
256.5-257°C |
| Solubility |
MeOH, Poor solubility in water. |
| Appearance |
White Crystalline Powder |
James SH, Prichard MN. Current and future therapies for herpes simplex virus infections: mechanism of action and drug resistance. Curr Opin Virol. 2014 Jul 15;8C:54-61. PMID: 25036916.
Katane M, Matsuda S, Saitoh Y, et al. The antiviral drug acyclovir is a slow-binding inhibitor of (D)-amino acid oxidase. Biochemistry. 2013 Aug 20;52(33):5665-74. PMID: 23859606.
Elion GB. Mechanism of action and selectivity of acyclovir. Am J Med. 1982 Jul 20;73(1A):7-13. PMID: 6285736.
