Acarbose
Acarbose is an anti-diabetic α-glucosidase inhibitor that decreases digestion of complex carbohydrates and prevents glucose absorption. Acarbose improves insulin sensitivity and decreases postprandial hyperglycemia.
References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/18835555
| Cas No. |
56180-94-0 |
|---|---|
| Purity |
≥98% |
| Formula |
C25H43NO18 |
| Formula Wt. |
645.6 |
| Chemical Name |
O-4,6-Dideoxy-4-[[[1S-(1α,4α,5-β,6α))-4,5,6- trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-α-D-glucopyranosyl-(1-4)-O-α-D-glucopyranosyl-(1-4)-D-glucose |
| IUPAC Name |
(3R,4R,5S,6R)-5-[(2R,3R,4R,5S,6R)-5-[(2R,3R,4S,5S,6R)-3,4-dihydroxy-6-methyl-5-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino]oxan-2-yl]oxy-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-(hydroxymethyl)oxane-2,3,4-triol |
| Synonym |
Bay g 5421; Glucobay; Prandase; Precose |
| Melting Point |
90°C |
| Solubility |
Soluble in water (129mg/mL), methanol, ethanol (8mg/mL), and DMSO (129mg/mL) |
| Appearance |
White to off white powder |
Kalra S. Alpha glucosidase inhibitors. J Pak Med Assoc. 2014 Apr;64(4):474-6. PMID: 24864650.
Okada K, Yanagawa T, Warabi E, et al. The alpha-glucosidase inhibitor acarbose prevents obesity and simple steatosis in sequestosome 1/A170/p62 deficient mice. Hepatol Res. 2009 May;39(5):490-500. PMID: 19207582.
Hoffmann J, Spengler M. Efficacy of 24-week monotherapy with acarbose, metformin, or placebo in dietary-treated NIDDM patients: the Essen-II Study. Am J Med. 1997 Dec;103(6):483-90. PMID: 9428831.
